SCART sequential lattice spatial fractionated radiotherapy combined with chemotherapy for recurrent ovarian cancer with bulky bone metastasis: a case report

The combination of SCART and Lattice techniques offers a promising strategy for managing bulky tumor, particularly suitable for cases with less-responsive to conventional therapy. This technique ensures safe dose at target margins while increasing dose to "cold tumor" areas, offering new clinical options. This approach safely escalates intratumoral dose while protecting normal tissue and may enhance immunogenic and cytotoxic responses. Sequential spatial fractionation techniques appear feasible, with controllable short-term safety and favorable tolerance.