PROTECTIVE EFFECTS OF GREEN TEA AND BILBERRY AGAINST SECONDARY HYPERLIPIDEMIA IN GENTAMICIN‒INDUCED NEPHROTOXICITY IN RATS

<p class="cvGsUA direction-ltr align-justify para-style-body" style="text-align: justify;"><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">The aim of this study was to examine whether green tea and bilberry have beneficial effects on secondary hyperlipidemia developed due to gentamicin-induced renal impairment. </span><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">GM group of rats was treated with gentamicin only, GT group was given green tea only, B group received bilberry only, while C group was given saline only. GT+GM group received green tea simultaneously with gentamicin, whereas B+GM group was given bilberry with gentamicin. </span><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">The results showed that gentamicin significantly increased total cholesterol, LDL and triglycerides, while it decreased HDL when compared with the control group. However, when either green tea or bilberry was applied together with gentamicin, this secondary hyperlipidemia was significantly ameliorated, as evidenced by a significant increase of HDL, and a decrease of LDL, cholesterol and triglycerides in comparison to GM group. </span><span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">The beneficial effects of both green tea and bilberry on secondary hyperlipidemia in gentamicin-induced nephrotoxicity occurred due to their powerful antioxidant properties. They are both functional foods, and</span> <span class="a_GcMg font-feature-liga-off font-feature-clig-off font-feature-calt-off text-decoration-none text-strikethrough-none">widely available in nature, and can be used as cost-effective additional therapy together with gentamicin, without affecting its activity in killing bacteria.</span></p>