Efficacy and Safety of the Kidney Function–Based Finerenone Dosing Strategy Used in FINEARTS-HF

In FINEARTS-HF, an eGFR-based dosing strategy allowed effective and safe use of finerenone in patients with heart failure with mildly reduced ejection fraction/ heart failure with preserved ejection fraction with a baseline eGFR as low as 25 mL/min/1.73 m<sup>2</sup>. We recommend that clinicians implement the trial-validated dosing strategy and incorporate appropriate uptitration to the target dose to ensure optimal therapeutic outcomes. (FINEARTS-HF [Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%; NCT04435626).

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Publication Details

Journal
JACC Heart Failure
Published
2026-02-01
DOI
https://doi.org/10.1016/j.jchf.2026.102938
Primary Topic
Heart Failure Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Efficacy and Safety of the Kidney Function–Based Finerenone Dosing Strategy Used in FINEARTS-HF

Grzegorz Gajos, Katja Rohwedder, Misato Chimura, Naoki Sato et al.
JACC Heart Failure
Heart Failure Treatment and Management
article

Efficacy and Safety of the Kidney Function–Based Finerenone Dosing Strategy Used in FINEARTS-HF

Grzegorz Gajos, Katja Rohwedder, Misato Chimura, Naoki Sato, Flaviana Amarante, John J.V. McMurray, James Lay-Flurrie, Michele Senni, Faiez Zannad, Mehmet B. Yilmaz, Brian L. Claggett, Carolyn S.P. Lam, Gerasimos Filippatos, Pardeep S. Jhund, Bertram Pitt, Scott D. Solomon, Meike Brinker, Akshay S. Desai, Muthiah Vaduganathan, Alasdair D. Henderson, Adriaan A. Voors
article en

Abstract

In FINEARTS-HF, an eGFR-based dosing strategy allowed effective and safe use of finerenone in patients with heart failure with mildly reduced ejection fraction/ heart failure with preserved ejection fraction with a baseline eGFR as low as 25 mL/min/1.73 m<sup>2</sup>. We recommend that clinicians implement the trial-validated dosing strategy and incorporate appropriate uptitration to the target dose to ensure optimal therapeutic outcomes. (FINEARTS-HF [Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40%; NCT04435626).

JACC Heart Failure
Jagiellonian University (PL), Brigham and Women's Hospital (US), University Medical Center Groningen (NL), Harvard University (US), Inserm (FR), National University of Singapore (SG), Dokuz Eylül University (TR), National and Kapodistrian University of Athens (GR), University of Michigan (US), British Heart Foundation (GB), Ospedale Papa Giovanni XXIII (IT), National University Heart Centre Singapore (SG), Institute of Cardiology (PL), Noguchi Hospital (JP), National Heart Centre Singapore (SG), Corona (Poland) (PL), University of Milano-Bicocca (IT), Bayer (Germany) (DE), University of Glasgow (GB), Université de Lorraine (FR)
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Heart Failure Treatment and Management
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