Design, Rationale, and Methods of the INITIATE-HFrEF Trial
Initiation of ARNi and SGLT2i in Patients With HFrEF is a randomized trial to test whether a simultaneous initiation of ARNi and SGLT2i is noninferior to a sequential initiation of one agent followed by the other 4 to 12 weeks apart.
Authors
- Mariana Pereira Santos (ORCID: https://orcid.org/0000-0001-6264-6067)
- Carlos Grijó (ORCID: https://orcid.org/0000-0002-7530-8750)
- Cristina Gavina (ORCID: https://orcid.org/0000-0003-2553-8264)
- María José Santos (ORCID: https://orcid.org/0000-0002-7946-1365)
- Joana Marantes Pimenta (ORCID: https://orcid.org/0009-0005-4413-4523)
- F S Saraiva
- R Fontes-Carvalho
- A. Simões Oliveira
- Inês Pereira-Sousa
- Rita Azevedo
- João Pedro Ferreira
- Francisco Vasques-Nóvoa
Institutions
- Instituto Superior de Contabilidade e Administracao do Porto (PT)
- Inserm (FR)
- Universidade do Porto (PT)
- Hospital de São João (PT)
- Hospital Pedro Hispano (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- French Clinical Research Infrastructure Network (FR)
Publication Details
- Journal
- JACC Advances
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1016/j.jacadv.2026.102589
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00