Cortical Layer‐Specific Remodelling of Parvalbumin and Perineuronal Net Networks in Alcohol Use Disorder
This study reveals layer-specific remodelling of PNN and PV networks in the human cortex in AUD cases, suggesting shifts in AUD behaviours are potentially attributed to PV neuronal activity regulated by PNN in specific cortical layers. Together, this study identifies AUD-related neuropathology and provides insight into the mechanisms underlying persistent alcohol-seeking behaviour.
Authors
- Asheeta A. Prasad (ORCID: https://orcid.org/0000-0001-9752-8175)
- Tamsin Karas
Institutions
- The University of Sydney (AU)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/nan.70066
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Sydney
- National Institutes of Health