Targeting the <scp>SIRT1</scp> ‐ <scp>NAT10</scp> ‐ <scp>GABABR1</scp> Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane‐Induced Cognitive Impairment in Aging
SIRT1 alleviates POCD by deacetylating NAT10 to reduce Gababr1 mRNA acetylation, thereby normalizing synaptic inhibition and restoring metabolic-autophagic balance. The SIRT1-NAT10-GABABR1 axis represents a novel therapeutic target for anesthesia-related neurotoxicity.
Authors
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Xin Xie (ORCID: https://orcid.org/0009-0000-0015-7794)
- Wei Du
- Yanmei Zhang
Institutions
- Liaoning Cancer Hospital & Institute (CN)
- China Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/cns.70762
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00