Serum total apoptosis inhibitor of macrophage, metabolomic signatures, and incident dyslipidemia: A population-based prospective study
Elevated baseline AIM concentrations were prospectively associated with the development of metabolic dyslipidemia in women, with a similar but nonsignificant trend in men, and with high LDL-C in women. The related metabolomic profile suggests enhanced lipolysis and altered lipid metabolism. Therefore, AIM may serve as a biomarker for future dyslipidemia, particularly for triglyceride and HDL-C dysregulation.
Authors
- Takamasa Ishikawa (ORCID: https://orcid.org/0009-0006-1032-561X)
- Toru Takebayashi (ORCID: https://orcid.org/0000-0002-8268-8026)
- Sei Harada (ORCID: https://orcid.org/0000-0003-2666-4932)
- Ryota Toki
- Shun Edagawa
- Masahiro Sugimoto
- Aya Hirata
- Naoko Miyagawa
- Tomonori Okamura
- Akiyoshi Hirayama
- Miho Iida
- Satoko Arai
Institutions
- Yamagata University (JP)
- University of Miyazaki (JP)
- Keio University (JP)
Publication Details
- Journal
- Journal of clinical lipidology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.jacl.2026.01.023
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00