Rethinking Multiple Myeloma Treatment: The Biological and Clinical Insights Guiding Immune-Based Combinations
Preclinical and clinical insights are reshaping how immune-based therapies are used in multiple myeloma. This review explores how optimizing the integration of natural and synthetic immunity can support a shift from disease control to deep, durable immune eradication, paving the way for personalized immune strategies tailored to individual immune profiles.
Authors
- Marcello Turi (ORCID: https://orcid.org/0000-0002-8760-1794)
- M. Raab
- Andrew J. Portuguese (ORCID: https://orcid.org/0000-0003-1010-4578)
- Cirino Botta
- Annamaria Gulla
- Kenneth C. Anderson
- Lilli S. Sester
- Hermann Einsele
- Antonio G. Solimando
- Madhav V. Dhodapkar
- Torsten Steinbrunn
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Fred Hutch Cancer Center (US)
- Department of Health (ES)
- Dana-Farber Cancer Institute (US)
- Universitätsklinikum Würzburg (DE)
- Candiolo Cancer Institute (IT)
- University of Bari Aldo Moro (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1158/2643-3230.bcd-25-0107
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00