Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis

By unifying diverse clinical and experimental observations within a multiscale mechanistic quantitative framework, the proposed model offers a robust tool for predicting CD4<sup>+</sup> T-cell dynamics and assessing the impact of physiological changes or interventions on immune homeostasis.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-04
DOI
https://doi.org/10.3389/fimmu.2026.1742817
Primary Topic
T-cell and B-cell Immunology
Type
article
Field-Weighted Citation Impact
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article

Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis

Gabriel Helmlinger, Gennady Alekseevich Bocharov, Victoria Kulesh, Kirill Peskov
Frontiers in Immunology
T-cell and B-cell Immunology
article

Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis

Gabriel Helmlinger, Gennady Alekseevich Bocharov, Victoria Kulesh, Kirill Peskov
article en

Abstract

By unifying diverse clinical and experimental observations within a multiscale mechanistic quantitative framework, the proposed model offers a robust tool for predicting CD4<sup>+</sup> T-cell dynamics and assessing the impact of physiological changes or interventions on immune homeostasis.

Frontiers in ImmunologyVol. 17
Sechenov University (RU), Lomonosov Moscow State University (RU), Institute of Numerical Mathematics (RU), Institute of Chemical Biology and Fundamental Medicine (RU), Quantitative BioSciences (US), Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences (RU), Moscow State University (TJ), Health Decisions (United States) (US)
Openalex Percentile: Top 67%
T-cell and B-cell Immunology
DOIOpen Access PDFOpenAlex
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Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis — Gabriel Helmlinger, Gennady Alekseevich Bocharov, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS