Identification of common genes and biomarkers between Dermatomyositis and rheumatoid arthritis through integrated bioinformatics

Integrative, ML-assisted transcriptomics reveals convergent RA-DM programmes centred on IL-17, TLR and chemokine pathways with remodelling of the immune microenvironment. HCP5 and RARRES3 emerge as reproducible, externally supported candidates with diagnostic potential and plausible links to macrophage polarisation and T-cell states. These findings nominate testable biomarkers and pathways for validation and provide a rationale for pathway-guided, cross-disease studies of RA-DM comorbidity.