Thermal preconditioning of targeted tissue enhances pulsed field ablation lesions
In this in vitro model, thermal preconditioning significantly alters PFA lesion formation. Increasing the tissue temperature prior to ablation markedly increases lesion diameter and depth, possibly by lowering the electroporation threshold. These findings suggest that tissue temperature is a tunable factor influencing PFA efficacy.
Authors
- Logan McClennen
- Nathaniel Steiger (ORCID: https://orcid.org/0000-0002-0475-0859)
- William H. Sauer (ORCID: https://orcid.org/0009-0006-8556-3612)
- Maxwell Coll (ORCID: https://orcid.org/0000-0002-2507-7587)
- Camila Ciurlo Aragón
- Daniel Campos-Villarreal
- Chieko Imamura
- Andres F Miranda-Arboleda
Institutions
- Brigham and Women's Hospital (US)
Publication Details
- Journal
- Journal of Interventional Cardiac Electrophysiology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1007/s10840-026-02247-4
- Citations
- 1
- Primary Topic
- Microbial Inactivation Methods
- Type
- article
- Field-Weighted Citation Impact
- 27.96