Persistent neutrophil activation despite count normalization suggests immune dysregulation in exertional heat stroke
In this exploratory study, our findings reveal a dissociation between neutrophil recruitment and activation in EHS. The persistent elevation of MPO and NE long after count normalization suggests a prolonged state of neutrophil dysregulation that could contribute to both acute tissue injury and long-term immune complications in EHS survivors.
Authors
- Siya Xu
- Zhongzhi Tang
- Yue Wang
- Jie Liu
Institutions
- University of Science and Technology of China (CN)
- Chinese Academy of Sciences (CN)
- Hefei Institutes of Physical Science (CN)
- People's Liberation Army No. 150 Hospital (CN)
- Anhui Institute of Optics and Fine Mechanics (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fimmu.2025.1718617
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Wannan Medical College
- Chinese People’s Liberation Army