Global Trials, Local Relevance: A Scientific and Regulatory Framework for Regional Enrollment in Cancer Drug Development
Regional enrollment should be viewed not as a regulatory formality, but as a scientific and ethical priority. The future of global oncology trials hinges on proactive regional planning, innovative methodology, and cross-sector collaboration. Aligning global efficiency with local relevance can enhance scientific robustness, support regulatory alignment, and expand equitable access to novel cancer therapies worldwide.
Authors
- Denis Horgan (ORCID: https://orcid.org/0000-0003-4392-4505)
- Jonathan A. Lal (ORCID: https://orcid.org/0000-0002-1929-1843)
- Roberto Carmagnani Pestana (ORCID: https://orcid.org/0000-0002-1141-7608)
- Ken Mastris (ORCID: https://orcid.org/0000-0002-6074-8147)
- Ramin Asgary (ORCID: https://orcid.org/0000-0001-7646-0976)
- Alejandro Mohar
- Zorana Maravic
- Vivek Subbiah
- Hesham Elghazaly
- Carolina Reduzzi
- Umberto Malapelle
- Hadi Mohamad Abu Rasheed
- Adda Bounedjar
Institutions
- Milken Institute (US)
- Cornell University (US)
- Sam Higginbottom Institute of Agriculture (IN)
- Hospital Israelita Albert Einstein (BR)
- Sarah Cannon (US)
- International Network for Cancer Treatment and Research (BE)
- European Organisation for Research and Treatment of Cancer (BE)
- Prostate Cancer UK (GB)
- Instituto Nacional de Cancerología (MX)
- Egyptian Society of Laboratory Medicine (EG)
- Weill Cornell Medicine (US)
- University of Blida (DZ)
Publication Details
- Journal
- JCO Global Oncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1200/go-25-00285
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 0.00