Direct detection of rare circulating tumor cells in peripheral blood mononuclear cells by scRNA seq: Spike-in strategy based feasibility study
This study confirms that single-cell analysis pipelines are competent, can effectively and correctly detect rare epithelial tumor cells in PBMCs with high sensitivity and reproducibility, even at very low concentrations.
Authors
- Apoorva Chaudhary
- Divya Janjua (ORCID: https://orcid.org/0009-0005-8057-1405)
- Udit Joshi
- Alok C. Bharti (ORCID: https://orcid.org/0000-0002-5996-2832)
- Anmol Mittal (ORCID: https://orcid.org/0000-0002-0689-387X)
- Tanya Tripathi
- Neha Tanwar
- Anmol
Institutions
- University of Delhi (IN)
Publication Details
- Journal
- The Journal of Liquid Biopsy
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1016/j.jlb.2026.100457
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 22.24
Funders
- Arthritis National Research Foundation
- National Research Foundation
- Indian Council of Medical Research
- University Grants Commission
- University of Delhi