Clinical Evidence of Valvelike Structures in Schlemm Canal and Their Anatomic Links Detected by Optical Coherence Tomography

This is the first clinical OCT evidence of valvelike structures in Schlemm canal, which were visualized in all 10 postoperative eyes. Based on structural and dimensional similarities, the authors hypothesize that the 3 in vivo clinical OCT structures closely resemble the SIV, HCF, and CVC. Our preliminary results bridge the gap from the laboratory to the clinic and add support to the addition of these 3 structures to the anatomy of the living human aqueous outflow system.

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Publication Details

Journal
American Journal of Ophthalmology
Published
2026-02-04
DOI
https://doi.org/10.1016/j.ajo.2026.01.032
Primary Topic
Optical Coherence Tomography Applications
Type
article
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article

Clinical Evidence of Valvelike Structures in Schlemm Canal and Their Anatomic Links Detected by Optical Coherence Tomography

A Liu, Matthew J. Holliman, R. D. Fellman, Xin Chen et al.
American Journal of Ophthalmology
Optical Coherence Tomography Applications
article

Clinical Evidence of Valvelike Structures in Schlemm Canal and Their Anatomic Links Detected by Optical Coherence Tomography

A Liu, Matthew J. Holliman, R. D. Fellman, Xin Chen, Steven Padilla, Elizabeth Martin, Davinder Grover, Ruikang K. Wang
article en

Abstract

This is the first clinical OCT evidence of valvelike structures in Schlemm canal, which were visualized in all 10 postoperative eyes. Based on structural and dimensional similarities, the authors hypothesize that the 3 in vivo clinical OCT structures closely resemble the SIV, HCF, and CVC. Our preliminary results bridge the gap from the laboratory to the clinic and add support to the addition of these 3 structures to the anatomy of the living human aqueous outflow system.

American Journal of OphthalmologyVol. 285
Washington State Department of Health (US), University of Washington (US), University of Illinois Chicago (US), Whitten Laser Eye (US), Beijing Anzhen Hospital (CN), Glaucoma Associates of Texas (US)
Openalex Percentile: Top 68%
Optical Coherence Tomography Applications
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Clinical Evidence of Valvelike Structures in Schlemm Canal and Their Anatomic Links Detected by Optical Coherence Tomography — A Liu, Matthew J. Holliman, et al. · American Journal of Ophthalmology (2026) | TGRS Research Map | TGRS