Endogenous <scp>GIP</scp> signaling is indispensable for <scp>DPP</scp> ‐4 inhibitor‐mediated metabolic control in mice
Endogenous GIP signaling is essential for both glucose-lowering and anti-obesity actions of DPP-4 inhibitors in mice. GLP-1 elevation alone is insufficient to compensate for GIP receptor deficiency. These findings refined the mechanistic understanding of DPP-4 inhibitors, highlighted the physiological importance of GIP, and suggested context-dependent metabolic actions of incretins.
Authors
- Toshinori Imaizumi (ORCID: https://orcid.org/0000-0001-8808-1893)
- Taro Fujisawa
- Yukio Horikawa (ORCID: https://orcid.org/0000-0001-7268-6871)
- T. Kato
- Katsumi Iizuka (ORCID: https://orcid.org/0000-0002-9837-6238)
- Sodai Kubota (ORCID: https://orcid.org/0000-0002-6072-0080)
- Shin Tsunekawa (ORCID: https://orcid.org/0000-0002-9890-5777)
- Hiromi Tsuchida (ORCID: https://orcid.org/0009-0004-1542-3900)
- Takaaki Murakami (ORCID: https://orcid.org/0000-0003-3844-1138)
- D. Yabe
- Saki Kubota‐Okamoto (ORCID: https://orcid.org/0009-0001-4747-6415)
- Hitoshi Kuwata (ORCID: https://orcid.org/0009-0000-5498-3282)
- Yuuka Fujiwara (ORCID: https://orcid.org/0009-0002-4151-457X)
- Yutaka Seino
- Seiya Banno
- Yoshihiro Takahashi
- Yuji Yamazaki
- Yanyan Liu (ORCID: https://orcid.org/0009-0008-0263-3596)
Institutions
- Fujita Health University (JP)
- Kyoto University (JP)
- Kansai Electric Power (Japan) (JP)
- Kansai Electric Power Hospital (JP)
- Gifu University (JP)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1111/jdi.70252
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Association for Diabetes Education and Care
- Boehringer Ingelheim Japan
- Japan Society for the Promotion of Science