Repeated fentanyl abstinence intensifies opioid withdrawal and induces a proinflammatory state in striatal microglia
Together these results suggest that mouse striatal microglia initiate a proinflammatory response following five, but not one, opioid exposure and withdrawal experiences and suggest that drug therapies targeting microglial innate immune responses may mitigate the severe withdrawal associated with repeated opioid tolerance and withdrawal.
Authors
- Matthew J. Wanat (ORCID: https://orcid.org/0000-0003-1643-6557)
- Aliyah J. Dawkins
- David J. Bergkamp (ORCID: https://orcid.org/0000-0002-6314-5544)
- Kevin R. Coffey (ORCID: https://orcid.org/0000-0001-9703-8790)
- Ari M. Peden-Asarch (ORCID: https://orcid.org/0009-0005-5534-9191)
- Madelyn T. Rice
Institutions
- Harvard University (US)
- University of Washington (US)
- VA Puget Sound Health Care System (US)
Publication Details
- Journal
- Psychopharmacology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.1007/s00213-026-07011-0
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Drug Abuse