Advancing CAR-T therapy in prostate cancer: overcoming the tumor microenvironment and enhancing efficacy
CAR-T therapy for prostate cancer is a rapidly advancing field. This review provides an updated perspective on CAR-T targets, engineering strategies, and combination approaches in PCa. Ongoing innovations in CAR design and therapeutic combinations offer the potential to develop more effective and durable CAR-T treatments for advanced prostate cancer.
Authors
- Kun Zhao (ORCID: https://orcid.org/0000-0002-4479-1102)
- Long Cheng (ORCID: https://orcid.org/0000-0002-7084-5821)
- Xi Xiao (ORCID: https://orcid.org/0000-0003-1495-4561)
- Zhongze Zhou
- Xiangbin Kong
- Yongfeng Lao
- Wenxuan Li
- Shuai Liu
- Zhilong Dong
Institutions
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-02-04
- DOI
- https://doi.org/10.3389/fonc.2026.1659869
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00