Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways
DISC1 represents a convergent therapeutic target for AD, mediating TSA's neuroprotective effects through pathways regulating GSK3β, mitochondrial transport, and synaptic plasticity, providing a mechanistic framework for developing AD therapeutics.
Authors
- Nur Jury (ORCID: https://orcid.org/0000-0002-1143-3595)
- J. Jillian Zhang (ORCID: https://orcid.org/0009-0007-7613-6966)
- Caleb Beimfohr
- Pengyue Zhang (ORCID: https://orcid.org/0000-0002-7381-9303)
- Madeline Peyton (ORCID: https://orcid.org/0009-0004-3921-5663)
- Jiahui Liu
- Kun Huang
- Cristian A. Lasagna‐Reeves
- Chitra Sunil
- Timothy I. Richardson
- Sean D. McCabe
Institutions
- Indiana University Health (US)
- Regenstrief Institute (US)
- Baylor College of Medicine (US)
- Cincinnati Health Department (US)
- Indiana Biosciences Research Institute (US)
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71108
- Primary Topic
- Phosphodiesterase function and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00