Integrated multicenter single-cell atlas of bladder cancer reveals tumor heterogeneity associated with immunotherapy
This study provides a robust single-cell framework for resolving inter- and intra-tumoral heterogeneity in BCa, overcoming limitations of bulk-based subtyping. The TGF-β1-PTHLH axis contributes to ICI resistance, positioning PTHLH as a promising therapeutic target. These findings offer new insights for improving immunotherapeutic strategies in BCa.
Authors
- Huiqing Wang
- Ziwei Wang (ORCID: https://orcid.org/0000-0002-8799-812X)
- Yidie Ying (ORCID: https://orcid.org/0000-0001-6707-9014)
- Shuxiong Zeng (ORCID: https://orcid.org/0000-0001-7656-9437)
- Meimian Hua
- Qing Chen (ORCID: https://orcid.org/0000-0002-2191-6558)
- Chuanliang Xu (ORCID: https://orcid.org/0000-0003-2622-8348)
- Yue Wang (ORCID: https://orcid.org/0000-0003-0098-5359)
- Maoyu Wang (ORCID: https://orcid.org/0000-0002-0022-187X)
- Zhensheng Zhang
- Chen Zhang
- Xufeng Yu
- Wei He
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-02-02
- DOI
- https://doi.org/10.1097/js9.0000000000003830
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00