Therapy for Stage IV Non–Small Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline, 2026.3.0
Evidence-based recommendations were updated to address first, second, and subsequent treatment options for patients without driver alterations.Additional information is available at www.asco.org/thoracic-cancer-guidelines.
Authors
- Jill Feldman (ORCID: https://orcid.org/0000-0002-2107-8240)
- Fawzi Abu Rous (ORCID: https://orcid.org/0000-0002-7458-9802)
- Amith Ahluwalia
- Carolyn Jean Presley (ORCID: https://orcid.org/0000-0002-2607-5639)
- Logan Roof (ORCID: https://orcid.org/0000-0002-9362-7851)
- Eric Kumar Singhi (ORCID: https://orcid.org/0000-0001-5918-9168)
- Paul Wheatley Price
- Naoki Furuya
- J. Reuss
- Jarushka Naidoo (ORCID: https://orcid.org/0000-0002-3470-8686)
- Narinder K. Malhotra
- Kristen Ashley Marrone (ORCID: https://orcid.org/0000-0001-5319-824X)
- Michael P. Mullane
- Gary R. MacVicar
- Deebya Raj Mishra (ORCID: https://orcid.org/0000-0003-1419-3803)
- Dwight Owen
- Erin Lynn Schenk (ORCID: https://orcid.org/0000-0001-9418-9948)
- Greg Andrew Durm (ORCID: https://orcid.org/0000-0003-2606-745X)
- Ibrahim Azar (ORCID: https://orcid.org/0000-0002-1008-1807)
- Krishna Alluri (ORCID: https://orcid.org/0000-0003-3157-9521)
- Lecia VanDam Sequist
- Sara Kuruvilla
- S. Puri
- B. Pellini
- J. Marie Suga
- Angel Qin
- Lyudmila Bazhenova
- Natasha B. Leighl
- Yubao Wang
- Navneet Singh
- Hidehito Horinouchi
- Ana I. Velazquez
- Toby Campbell
- Narjust Florez
- Shirish Gadgeel
- Janet Freeman-Daily
- Balazs Halmos
Institutions
- Aurora Health Care (US)
- Indiana University Health (US)
- Baptist Hospital of Miami (US)
- Albert Einstein College of Medicine (US)
- American Society of Clinical Oncology (US)
- University Health Network (CA)
- Montefiore Medical Center (US)
- John Muir Health (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- Johns Hopkins University (US)
- University of Ottawa (CA)
- Henry Ford Health System (US)
- St. Marianna University School of Medicine (JP)
- University of California, San Francisco (US)
- Georgetown University (US)
- The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (US)
- Texas Oncology (US)
- Ottawa Hospital (CA)
- London Health Sciences Centre (CA)
- Princess Margaret Cancer Centre (CA)
- Johns Hopkins Bayview Medical Center (US)
- Moffitt Cancer Center (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- Baptist Health South Florida (US)
- Michigan Medicine (US)
- Dana-Farber Cancer Institute (US)
- Kaiser Permanente Vallejo Medical Center (US)
- Illinois CancerCare (US)
- Wenatchee Valley Hospital & Clinics (US)
- Tokyo National Hospital (JP)
- Sidney Kimmel Comprehensive Cancer Center (US)
- IHA Hematology Oncology Consultants (US)
- Montefiore Einstein Comprehensive Cancer Center
- Post Graduate Institute of Medical Education and Research (IN)
- University of Colorado Anschutz Medical Campus (US)
- The Ohio State University (US)
- Indiana University – Purdue University Indianapolis (US)
- B.P. Koirala Institute of Health Sciences (NP)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1200/jco-25-02825
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00