Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease
Collectively, our findings define TFAM K76 acetylation as a pathogenic driver of DKD and propose C14 as a promising therapeutic candidate targeting mitochondrial metabolism.
Authors
- Qian Mu (ORCID: https://orcid.org/0000-0002-9839-1980)
- Fuyuan Xue
- Junhui Zhen
- Qiang Wan
- Shengnan Sun
- Zhiye Wang
- Ying Wang
- Xingzhao Ji
- Tingting Fu
- Fang Zhao
- Yi Liu
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Jinan Central Hospital (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Qilu Hospital of Shandong University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s12933-026-03089-0
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00