Optimisation of the Primary De-bagging Step for Double-bag Products Within Aseptic Production Processes
This paper presents a comprehensive optimisation and evaluation of an automated de-bagging process for aseptic manufacturing, where a double-bagged product must be transferred from a non-sterile to a highly sterile environment. The current system experiences a high failure rate, with a success rate of only $$\varvec{30~\%}$$ in the initial de-bagging step, leading to significant product loss and production downtime. Through a series of empirical, mechanical, and push-out force-based optimisations, including improvements to the product guide rails, clamping mechanisms, and pusher bar operation the success rate of the de-bagging process was increased to $$\varvec{89~\%}$$ . Based on the results a set of generalised recommendations was formalised for the design of other de-baggers. Part of the suggested optimisation methods have since been integrated in a real de-bagger setup, which shows similar results to those achieved in the test setup.
Authors
- Gert Schouterden (ORCID: https://orcid.org/0000-0002-8391-0514)
- Ivo Dekker (ORCID: https://orcid.org/0000-0003-3543-4282)
- Karel Kellens (ORCID: https://orcid.org/0000-0002-0340-6669)
- Rafaël Verbiest (ORCID: https://orcid.org/0000-0002-2254-7475)
- Eric Demeester (ORCID: https://orcid.org/0000-0001-6866-3802)
- David De Schepper (ORCID: https://orcid.org/0000-0003-2090-0076)
- Anton Melnikov
Institutions
- Imec the Netherlands (NL)
- Flanders Make (Belgium) (BE)
Publication Details
- Journal
- Journal of Pharmaceutical Innovation
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1007/s12247-026-10392-6
- Primary Topic
- Advanced Manufacturing and Logistics Optimization
- Type
- article
- Field-Weighted Citation Impact
- 0.00