Optimisation of the Primary De-bagging Step for Double-bag Products Within Aseptic Production Processes

This paper presents a comprehensive optimisation and evaluation of an automated de-bagging process for aseptic manufacturing, where a double-bagged product must be transferred from a non-sterile to a highly sterile environment. The current system experiences a high failure rate, with a success rate of only $$\varvec{30~\%}$$ in the initial de-bagging step, leading to significant product loss and production downtime. Through a series of empirical, mechanical, and push-out force-based optimisations, including improvements to the product guide rails, clamping mechanisms, and pusher bar operation the success rate of the de-bagging process was increased to $$\varvec{89~\%}$$ . Based on the results a set of generalised recommendations was formalised for the design of other de-baggers. Part of the suggested optimisation methods have since been integrated in a real de-bagger setup, which shows similar results to those achieved in the test setup.

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Publication Details

Journal
Journal of Pharmaceutical Innovation
Published
2026-02-03
DOI
https://doi.org/10.1007/s12247-026-10392-6
Primary Topic
Advanced Manufacturing and Logistics Optimization
Type
article
Field-Weighted Citation Impact
0.00
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article

Optimisation of the Primary De-bagging Step for Double-bag Products Within Aseptic Production Processes

Gert Schouterden, Ivo Dekker, Karel Kellens, Rafaël Verbiest et al.
Journal of Pharmaceutical Innovation
Advanced Manufacturing and Logistics Optimization
article

Optimisation of the Primary De-bagging Step for Double-bag Products Within Aseptic Production Processes

Gert Schouterden, Ivo Dekker, Karel Kellens, Rafaël Verbiest, Eric Demeester, David De Schepper, Anton Melnikov
article en

Abstract

This paper presents a comprehensive optimisation and evaluation of an automated de-bagging process for aseptic manufacturing, where a double-bagged product must be transferred from a non-sterile to a highly sterile environment. The current system experiences a high failure rate, with a success rate of only $$\varvec{30~\%}$$ in the initial de-bagging step, leading to significant product loss and production downtime. Through a series of empirical, mechanical, and push-out force-based optimisations, including improvements to the product guide rails, clamping mechanisms, and pusher bar operation the success rate of the de-bagging process was increased to $$\varvec{89~\%}$$ . Based on the results a set of generalised recommendations was formalised for the design of other de-baggers. Part of the suggested optimisation methods have since been integrated in a real de-bagger setup, which shows similar results to those achieved in the test setup.

Journal of Pharmaceutical InnovationVol. 21(2)
Imec the Netherlands (NL), Flanders Make (Belgium) (BE)
Openalex Percentile: Top 69%
Advanced Manufacturing and Logistics Optimization
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Optimisation of the Primary De-bagging Step for Double-bag Products Within Aseptic Production Processes — Gert Schouterden, Ivo Dekker, et al. · Journal of Pharmaceutical Innovation (2026) | TGRS Research Map | TGRS