Gum Arabic Modulates Redox–Ionic Microenvironments via Rheology and Kinetics to Induce Selective Cytotoxicity in Colorectal Cancer Cells
These findings demonstrate that GA functions as a natural, ion-responsive biopolymeric system with defined rheological and kinetic properties, capable of selectively targeting colorectal cancer cells through coordinated genetic and ionic regulation of oxidative stress. Collectively, the results position GA as a promising functional gel-based platform for future redox-modulated therapeutic strategies in colorectal cancer.
Authors
- Ahmet Arif Kurt (ORCID: https://orcid.org/0000-0002-3490-0192)
- Ertuğrul Osman Bursalıoğlu (ORCID: https://orcid.org/0000-0002-2882-7435)
- Şükran Özdatlı Kurtuluş (ORCID: https://orcid.org/0000-0002-5735-7276)
- Şahin Yılmaz (ORCID: https://orcid.org/0000-0003-1126-1073)
- Büşra Yüksel (ORCID: https://orcid.org/0000-0001-8240-4866)
- Şaban Kalay (ORCID: https://orcid.org/0000-0002-9363-0073)
- Emre Cebeci (ORCID: https://orcid.org/0000-0002-6711-055X)
- Halise Betül Gökçe
- Mustafa Eray Bozyel
- Ismail Aslan
- Fikrettin Şahin
- Reyhan Aliusta
Institutions
- Yeditepe University (TR)
- Ministry of Industry and Trade (CZ)
- Başkent University (TR)
- Suleyman Demirel University (KZ)
- Sağlık Bilimleri Üniversitesi (TR)
- ODTÜ Teknokent (Turkey) (TR)
- Teknoloji Arastirma ve Gelistirme Endustriyel Urunler Bilisim Teknolojileri San Tic (TR)
- Afyonkarahisar Sağlık Bilimleri Üniversitesi
- Afyon Kocatepe University (TR)
- Sinop University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Gels
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3390/gels12020139
- Primary Topic
- Polysaccharides Composition and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00