Estimated Effectiveness of 2024-2025 COVID-19 Vaccination Against Severe COVID-19
In this multicenter, case-control analysis of VE, 2024-2025 COVID-19 vaccines may have provided protection against hospitalizations and severe in-hospital outcomes as multiple JN.1 descendant lineages circulated. Monitoring COVID-19 VE, including stratifying by SARS-CoV-2 lineage and spike protein mutations, remains important to guide COVID-19 vaccine composition and recommendations.
Authors
- Rylie McBride
- Amy Sullivan (ORCID: https://orcid.org/0000-0003-3036-6719)
- SHEKHAR A GHAMANDE
- Ithan D. Peltan (ORCID: https://orcid.org/0000-0003-1730-234X)
- Megan Mitchell
- C. Anderson Johnson (ORCID: https://orcid.org/0000-0002-5660-7026)
- Cristie Columbus (ORCID: https://orcid.org/0000-0001-5859-4786)
- Sydney A. Cornelison
- CAMERON D HYPES
- Yvette Renee Evans
- Adam S. Lauring (ORCID: https://orcid.org/0000-0003-2906-8335)
- Therissa Grefsrud
- Anne P. Frosch
- Leonard Basobas
- J. Bansal
- Nicholas M. Mohr (ORCID: https://orcid.org/0000-0003-0497-5828)
- Chiraag Balsara
- Olivia G. Arter
- Douglas Scaffidi
- Abby Schachter Fink
- Jenny Chan
- Kelsey N. Womack (ORCID: https://orcid.org/0000-0002-4628-8615)
- Nathaniel M. Lewis (ORCID: https://orcid.org/0000-0001-7088-9640)
- Bijal A. Parikh (ORCID: https://orcid.org/0000-0003-2490-8294)
- Barbara J. Hairston
- Michael Garcia (ORCID: https://orcid.org/0000-0001-5452-2726)
- Lesley de Souza
- Tyler Haley
- Izza Imran
- Leigh Papalambros
- Carlo Ottanelli
- Amer Charif
- Joshua C. Acidera (ORCID: https://orcid.org/0009-0002-3891-7976)
- Tresa A McNeal
- Arda Yigitkanli
- Omar Mehkri
- Steven Y. Chang
- Daniela Gonzalez
- Alyssa Valencia
- C. Pérez (ORCID: https://orcid.org/0009-0001-9824-7989)
- Mayur Ramesh
- Karen Lutrick
- Vanessa Pitre
- Elianora Ovchiyan
- Ivan Valesquez
- Erika V. Alor
- Jocelyn Cravens
- Aleda M. Leis
- Wesley H. Self
- Laurynn Giles
- Akram Khan
- Matthew Exline
- Diya Surie
- Nida Qadir
- Paul W. Blair
- Kalee E Rumfelt
- Gina E Maki
- Regine Burton
- Lucy Vogt
- Akshay Saluja
- Maile McKeown
- Kelsey N. Womack
- Kevin Ma
- Emily E. Bendall
- Davika Dige
- Rachel Truson
- Mildred Wallace
- Leah Odame-Bamfo
- Anne Zepeski
- Adrian Hernandez
- Fatimah S. Dawood
- Ibrahim Abu Hammad
- Rae Lynn Defeo
- Nicole Calhoun
- Maria Santana-Garces
- Michael Bolstad
- Claudia Guevara
- Christopher Mallow
- Spencer Rose
- Nicholas J. Johnson
- Connie Tran
- Jozyan Ujmaya
- William J. Fitzsimmons
- Amanda Martinez
- Bryan Poynter
- Alexander Webber
- Kimberly Redman
- Catherine Raver
- Gabriela Perez
- Scott Ouellette
- Sindhuja Koneru
- Vineela Thumma
- Priyanka Rana
- Arnaldo Devilla
- Catherine L. Hough
- Victoria Harkins Walston
- Beth Salvagio Campbell
- Noble Briggs
- Minh Phan
- Caroline O'Neil
- Rashil Madan
- Michael Smith
- Thomas Sturges
- Alexander Weingart
- Yuwei Zhu
- Kiran Ashok
- Genesis Briceno
- Conor Higgins
- Samantha Ferguson
- Mariana Hurutado-Rodriguez
- Brianna Coviello
- Anabelle Blue
- Laura Short
- Adrienne Baughman
- Robert L. Gottlieb
- Nathan I. Shapiro
- Sarah Karow
- Carlos G. Grijalva
- Bryan Peterson
- Adit A. Ginde
- H. Keipp Talbot
- Zachary Griffith
- Dylan Clark
- Brooke Lee
- Colleen Ratcliff
- Weronika Damek Valvano
- Joslyn Bassett
- Amanda McKillop
- Ine Sohn
- Cynthia Kardos
- Caitlin ten Lohuis
- Jay Steingrub
- Amy Segura
- Maryiam Khan
- Cody Tran
- William Bender
- Basmah Safdar
- Jennie H. Kwon
- Samantha Simon
- Todd W. Rice
- Abhijit Duggal
- Francesca Yerbic
- Paul Nassar
- Hannah Strait
- Rebecca Fong
- Kowsar Hurreh
- Rendie McHenry
- Safa Saeed
- Amira Mohamed
- Tammy Fisher
- Michelle N. Gong
- Estelle S. Harris
- Carleigh Samuels
- Amane Rasul
- Catherine McKeon
- Jonathan D. Casey
- Alexandra June Gordon
- Anne Kaniclides
- Kim Vu
- Laura Aguilar-Marquez
- Symone Dunkley
- David N. Hager
- Matthew E. Prekker
- Alycia Lilla
- Mary O'Rourke
- Sukantha Chandrasekaran
- Abigail Carolan
- Kempapura Murthy
- David McDonald
- Kirstina Luikart
- Denisse Mariscal
- Ashley Bychkowski
- Sydney Buehrig
- Cara Lwin
- Emily Tribbett
- Lily Lau
- Bryce Heslop
- Riya Matthew
- Audrey Hendrickson
- Omai Garner
- Sachina Mensah
- Regina Lehmann
- Anirudh Goyal
- Jennifer G. Wilson
- Joanna Kuo
- Jacob Rademacher
- Jennifer Luther
- Gabrielle Swoope
- Stacy Batey
- James D. Chappell
- Frances Nagore
- Jacob Hampton
- Julio Angulo
- Natasha Halasa
- Robert Ciottone
- Shruti Tirumala
Institutions
- University of Iowa (US)
- Centers for Disease Control and Prevention (US)
- Albert Einstein College of Medicine (US)
- Cleveland Clinic (US)
- Montefiore Medical Center (US)
- University of Arizona (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Emory University (US)
- Henry Ford Health System (US)
- University of California, Los Angeles (US)
- Oregon Health & Science University (US)
- Baylor College of Medicine (US)
- National Center for Immunization and Respiratory Diseases (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- University of Utah (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Hennepin County Medical Center (US)
- University of Utah Hospital (US)
- Intermountain Medical Center (US)
- Yale University (US)
- University of Utah Health Care (US)
- Baylor Scott & White Health (US)
- Wake Forest University (US)
- The Ohio State University (US)
- Vanderbilt University Medical Center (US)
- Texas A&M University (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.57415
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 98.35