D2Rs Agonist Ropinirole Cooperates with Metformin to Modulate Thermogenesis and Ameliorate Obesity-Related Metabolic Disorders in Mice
Our study underscores the combination of metformin and ropinirole-induced an amplified effectiveness in treating obesity-related metabolic disorders is dependent on the dopamine-control sympathetic nerve activity, and metformin acts directly on BAT and iWAT to improve mitochondrial function, which offering a new perspective for future clinical co-treatment of metabolic disorders with these two drugs.
Authors
- Fakun Jiang
- Daowei Liu
- Bangrui Huang
- Tao Chen
- Chuanjun Mao
- Qian Wang
- Wenli Chen
- Chun Xie
- Zihui Wang
- Qian Lu
Institutions
- Kunming Institute of Botany (CN)
- Yunnan University (CN)
- Chinese Academy of Sciences (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2026-02-04
- DOI
- https://doi.org/10.4093/dmj.2025.0335
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00