Single-cell profiling reveals reprogrammed hierarchy and disrupted immune-stromal ecosystem in TP53-mutated AML
This study provides the first single-cell landscape of de novo TP53-mutated AML, highlighting its reprogrammed leukemic hierarchy and disrupted immune-stromal ecosystem, and offering mechanistic insights and potential therapeutic targets for this high-risk subtype.
Authors
- Rongtao Xue (ORCID: https://orcid.org/0000-0001-7269-4708)
- Guo Qiu
- Cuiyan Zhou
- Xuan Li (ORCID: https://orcid.org/0000-0001-9352-6375)
- Ke Zhao (ORCID: https://orcid.org/0000-0002-8262-4989)
- Yanjia Ai
- Luting Wang
- Zhao Yin
- Pengcheng Shi
- Xi Xu
- Guopan Yu
- Shengjiao Tang
- Xueping Huang
- Sijian Yu
- Meng Shan
- Hui Liu
- Menglin Fan
- Xiaoyue Lu
- Guangmei Xiang
- Yu Zhang
- Yu Fei Wang
- Jing Xiong
- Qifa Liu
Institutions
- Peking University (CN)
- Soochow University (CN)
- Longgang Central Hospital (CN)
- Nanfang Hospital (CN)
- Peking University People's Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s40164-026-00751-x
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 70.83
Funders
- National Natural Science Foundation of China
- Young Scientists Fund