Persistently high prevalence of HPV16 and rising prevalence of non-16/18 HR-HPV genotypes in cervical precancer and cancer in Latvia in 2016-2024 shape the severity of cervical disease

HPV16 remained the most prevalent HR-HPV, while HPV18 decreased. Other HR-HPV genotypes (HPV 66/45/39/31/33) demonstrated an increase in prevalence. Cervical disease severity was linked to specific HR-HPV loads and the number infecting HR-HPVs. These findings highlight the need for extended HR-HPV genotyping with determination of viral load, and request more epidemiological studies analyzing historical and current samples.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-02-04
DOI
https://doi.org/10.3389/fonc.2025.1676334
Primary Topic
Cervical Cancer and HPV Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Persistently high prevalence of HPV16 and rising prevalence of non-16/18 HR-HPV genotypes in cervical precancer and cancer in Latvia in 2016-2024 shape the severity of cervical disease

Arta Spridzāne, Karina Biserova, Lība Sokolovska, Dmitry Perminov et al.
Frontiers in Oncology
Cervical Cancer and HPV Research
article

Persistently high prevalence of HPV16 and rising prevalence of non-16/18 HR-HPV genotypes in cervical precancer and cancer in Latvia in 2016-2024 shape the severity of cervical disease

Arta Spridzāne, Karina Biserova, Lība Sokolovska, Dmitry Perminov, Jurijs Nazarovs, Androniks Mitiļdžans, Maria Isaguliants, Daira Krišāne, Svetlana Gebrila, Juris Jansons, Ilvija Krasovska, Marta Petrovska, Beatrise Orlova, Alesja Dudorova
article en

Abstract

HPV16 remained the most prevalent HR-HPV, while HPV18 decreased. Other HR-HPV genotypes (HPV 66/45/39/31/33) demonstrated an increase in prevalence. Cervical disease severity was linked to specific HR-HPV loads and the number infecting HR-HPVs. These findings highlight the need for extended HR-HPV genotyping with determination of viral load, and request more epidemiological studies analyzing historical and current samples.

Frontiers in OncologyVol. 15
Latvian Biomedical Research and Study Centre (LV), Global University Systems (GB), Karolinska Institutet (SE), Riga East University Hospital (LV), Pauls Stradiņš Clinical University Hospital (LV), Riga Stradiņš University (LV), Central Research Laboratories (United Kingdom) (GB)
Good health and well-being
Openalex Percentile: Top 66%
Cervical Cancer and HPV Research
DOIOpen Access PDFOpenAlex
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Persistently high prevalence of HPV16 and rising prevalence of non-16/18 HR-HPV genotypes in cervical precancer and cancer in Latvia in 2016-2024 shape the severity of cervical disease — Arta Spridzāne, Karina Biserova, et al. · Frontiers in Oncology (2026) | TGRS Research Map | TGRS