Abnormal Regional Brain Functional Activity and Brain Network Connectivity in Primary Trigeminal Neuralgia Patients: An Activation Likelihood Estimation Meta-Analysis Based on Resting-State fMRI

Our meta-analysis demonstrates that PTN involves complex, multidimensional brain remodeling, not a dysfunction of a single "pain center." The distinct spatial patterns identified by different rs-fMRI metrics underscore their complementary value in uncovering PTN pathophysiology. These findings advance the understanding of PTN's central mechanisms, support the development of targeted interventions, and highlight the need to differentiate neurophysiological metrics and clinical subtypes in future research.