Exploring Sex Differences in Stroke Outcomes: A Comprehensive Analysis From the SPAN 1 Trial
In this multicenter preclinical study, we did not detect sex differences in stroke outcomes in mice, although sex differences in behavioral outcomes were observed in spontaneously hypertensive rats. These findings highlight that sex differences may be model-specific and subtle, emphasizing the need for methodological consistency and thoughtful inclusion of diverse animal models in translational stroke research to better understand if sex-specific responses contribute to stroke outcomes.
Authors
- Louise D. McCullough (ORCID: https://orcid.org/0000-0002-8050-1686)
- Anjali Chauhan (ORCID: https://orcid.org/0000-0002-9825-8100)
- David C. Hess
- Márcio A. Diniz
- Lauren H. Sansing
- Jaroslaw Aronowski
Institutions
- University of Iowa (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Augusta University (US)
- Keck Hospital of USC (US)
- Yale University (US)
- Massachusetts General Hospital (US)
- The University of Texas Health Science Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1161/jaha.125.043220
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00