Anatomical location of metastatic sentinel lymph node and clinicopathological characteristics for predicting risk of non-sentinel lymph node metastasis

Metastatic SLN location relative to the ICBN is a novel anatomical predictor of non-SLN metastasis. A nomogram incorporating this variable demonstrated good discrimination and clinical utility in a single-center cohort with temporal validation; prospective multicenter validation with standardized ICBN assessment is warranted before broader implementation.