Sleep Alters the Velocity of Physiological Brain Pulsations in Humans
Phantom studies validated the optic flow analysis of fast MREG recordings. Sleep altered the 3D velocity dynamics of all neurofluidic brain pulsations in a manner consistent with increased interstitial space and greater fluid exchange, thus supporting the glymphatic model wherein physiological pulsations drive bulk flow during sleep.
Authors
- Zalán Rajna (ORCID: https://orcid.org/0000-0003-3620-3304)
- Ahmed Elabasy (ORCID: https://orcid.org/0000-0001-9693-8965)
- Kiviniemi Vj
- Mika Kaakinen (ORCID: https://orcid.org/0000-0002-1229-8196)
- Matti Järvelä (ORCID: https://orcid.org/0000-0001-9899-3570)
- Lauri Raitamaa (ORCID: https://orcid.org/0000-0003-2884-6510)
- Tapio Seppänen (ORCID: https://orcid.org/0000-0002-3963-0750)
- Tommi Väyrynen (ORCID: https://orcid.org/0000-0003-4123-5917)
- Heta Helakari (ORCID: https://orcid.org/0000-0002-4354-4687)
- M. Kallio
- Ville Isokoski
- Niko Huotari
- Vesa Korhonen
- Johanna Piispala
Institutions
- Oulu University Hospital (FI)
- Oulu University of Applied Sciences (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1002/advs.202503745
- Citations
- 1
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 23.21