Dual Specificity Phosphatase (DUSP22) promoter hypomethylation in cell-free DNA is associated with rheumatoid arthritis and its radiographic severity
Our pilot study is the first to evaluate cfDNA methylation association to RA clinical characteristics. These exploratory findings suggest that <i>DUSP22</i> cfDNA methylation may represent a promising non-invasive biomarker in rheumatoid arthritis, a hypothesis that warrants validation in larger and ethnically diverse populations.
Authors
- Shante Hinson
- Milena Rodríguez Álvarez (ORCID: https://orcid.org/0000-0002-2845-5766)
- Toni-Ann T. Bravo
- N. Petraco
- Lissette Anthony Delgado-Cruzata
- Wallis Tavarez
- Menachem Gold
- Edgardo Guzman
- Alorah D. Bliese
Institutions
- Lincoln Medical Center (US)
- New York City Health and Hospitals Corporation (US)
- State University of New York (US)
- City University of New York (US)
- SUNY Downstate Health Sciences University (US)
- Boehringer Ingelheim (United Kingdom) (GB)
- John Jay College of Criminal Justice (US)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fmed.2026.1730527
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00