Lynch Syndrome as a Spectrum of Four Distinct Genetic Disorders: Toward Genotype-Guided Precision Management in the NGS Era
Genotype-specific precision management optimizes the benefit-burden balance, enhances early cancer detection, reduces overtreatment, and enables personalized genetic counseling, advancing precision healthcare for LS families and addressing critical gaps in hereditary cancer care.
Authors
- Shengwei Ye (ORCID: https://orcid.org/0000-0001-9543-9857)
- Zhen Liu (ORCID: https://orcid.org/0000-0003-3103-4011)
- Zhen Chen (ORCID: https://orcid.org/0009-0007-7842-5446)
- Xinjun Liang
- Yuanyuan Liu
Institutions
- Central China Normal University (CN)
- Hubei Cancer Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cancers
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3390/cancers18030506
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Xisike Clinical Oncology Research Foundation