Syndromic Surveillance—Review on Different Practices’ Performance and Added Value for Public Health

Timely identification of infectious disease threats is essential for public health readiness. Conventional indicator-based surveillance systems, while dependable for tracking established pathogens, frequently lack the agility and sensitivity to detect new infections promptly. Syndromic surveillance, which examines pre-diagnostic and non-specific health indicators from many data sources in near real time, serves as a significant complementary method that improves early warning and situational awareness. This narrative study analysed selected experiences with syndromic surveillance, utilising peer-reviewed literature and institutional records. Four primary data streams were examined: emergency department and hospital records, pharmacy and over the counter (OTC) sales, participative citizen-generated data, and hybrid multi-source systems. Syndromic indicators were reported to identify outbreaks two to fourteen days before standard laboratory reporting across many trials. Data from the emergency department exhibited the highest sensitivity and specificity (47.34% and 91.95%, respectively), whereas pharmacy and participative data offered early indicators at the community level. Integrated systems like ESSENCE (Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA) and SurSaUD^® (Saint-Maurice cedex, Paris, France) attained enhanced accuracy yet necessitated significant data integration and governance capabilities. Syndromic surveillance enhances epidemic preparation by detecting atypical health-seeking behaviours and variations from baseline patterns prior to formal diagnosis. Nonetheless, its efficacy is contingent upon data quality, interoperability, and contextual adaptation. Countries like Bulgaria could improve national early-warning capabilities and overall health security through the gradual adoption of pilot projects and integration with existing surveillance networks.