Super-enhancer-driven TCF4 orchestrates neuroblastoma metastasis by sphingolipid-dependent membrane remodeling and ITGB1-FAK activation
Our findings indicate that SE-driven TCF4 can orchestrate metastatic transcriptional networks to maintain NB malignancy and propose ACY-1215 as a translational therapeutic candidate for clinical intervention.
Authors
- Yueyuan Zheng (ORCID: https://orcid.org/0000-0002-5692-8903)
- Enzhe Lou
- Xianping Shi
- Shiwen Hu (ORCID: https://orcid.org/0000-0003-3407-4465)
- Bingyuan Liu
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Liling Jiang (ORCID: https://orcid.org/0000-0002-0057-2143)
- Jinxin Fang
- Qiong Mao
- Chunxia Shi
- Lizhen Jiang
- Jian Pan
- Xinyue Li (ORCID: https://orcid.org/0009-0009-5562-5458)
- Huan Zhou
- Ran Zhuo
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Soochow University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Children's Hospital of Suzhou University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1093/neuonc/noag021
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00