Depletion of <i>Sorcs3</i> Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways (Adv. Sci. 7/2026)
Shuai, and colleagues report that knocking out sorcs3 or inhibiting three key pathways can efficiently activate the totipotency of stem cells.The hall of totipotency is a lofty and desirable goal, and the path to it is fraught with challenges.The findings of this study are like a shortcut to aid the climb toward totipotency.
Authors
- Ling Shuai (ORCID: https://orcid.org/0000-0003-0671-7478)
- Qingshen Jia
- Yuan Shi (ORCID: https://orcid.org/0000-0002-8780-5420)
- Dan Ding (ORCID: https://orcid.org/0009-0001-9620-1960)
- Qian Gao
- Xinyu Mao
- Yu He
- Shengyi Sun
- Xiaoyan Sheng
- Wenhao Zhang
- Xiaomeng Dai
- Yiding Zhao
- Xiaoyan Li
Publication Details
- Journal
- Advanced Science
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/advs.73665
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00