Visible Light-Mediated [3 + 2] Cycloadditions of Vinylcyclopropanes with Alkenes/Alkynes Using CBr <sub>4</sub> and an Organic Photocatalyst
Utilizing a readily available and highly efficient organic photocatalyst (QXPT-NPy, 0.5 mol %) and inexpensive CBr<sub>4</sub> (0.5 mol %) as a bromine radical precursor, the [3 + 2] cycloadditions of vinylcyclopropanes with alkenes/alkynes were successfully achieved under irradiation of 420 nm blue LEDs. A broad scope of alkenes and alkynes participated efficiently in the reaction, and structurally diverse cyclopentane and cyclopentene derivatives were afforded in up to 97% yield and 95:5 dr.
Authors
- ZhongWen Wang
- Jun Ren (ORCID: https://orcid.org/0000-0001-8589-3810)
- Yanting Yang
- Yi Sun (ORCID: https://orcid.org/0009-0001-7923-3557)
- Lin Yuan
- Qiang Bian
Institutions
- Nankai University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1021/acs.joc.5c02490
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00