(PNM-36) Psychiatric comorbidities in patients with premature ejaculation: a narrative literature review

Abstract Introduction/Objective Premature ejaculation (PE) is a prevalent male sexual dysfunction frequently associated with psychiatric comorbidities. Despite their clinical importance, these links remain underexplored in psychiatric and sexological contexts. This study reviewed recent literature on psychiatric comorbidities in PE, focusing on evaluation tools and evidence levels. Materials and Methods We conducted a narrative review using articles from PubMed, BVS-LILACS, SciELO, and Google Scholar, published from 2010 to 2025. Eligible studies evaluated comorbidities such as anxiety, depression, obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and substance use in patients with PE. Ten articles met inclusion criteria and were analyzed for design, instruments, findings, and limitations. Results Anxiety was the most frequently reported comorbidity, affecting up to 75% of PE patients. Depression was present in up to 50%, often co-occurring with anxiety. ADHD was found in 42.1% of patients in one case–control study. Other associations included perceived stress, obsessive traits, and neurodevelopmental features. Most studies used standardized tools like PEDT, DSM-IV but also self-reported latency time. Designs included cross-sectional, retrospective, and case–control models. Common limitations were small sample sizes, lack of control groups, and reliance on self-report. Conclusions Evidence consistently links PE to anxiety and depressive disorders. These conditions may influence symptom onset and treatment response. Routine psychiatric assessment is advised. Further longitudinal research is needed to clarify associations and guide integrated care. Financing No conflict.