Carbon-Coordinated Cobalt Electrochemical Nanoplatform Enables in Vivo Selective Monitoring of Neurochemical Dysregulation in Glioblastoma-Infiltrated Brain

Longitudinal monitoring of neurochemical dysregulation during glioblastoma (GBM) progression is essential for elucidating tumor-neuron interactions and advancing neuroprotective strategies. Current methods, however, are limited by insufficient temporal resolution, spatial precision, and operational stability in the complex tumor microenvironment. We present a microelectrode sensing platform featuring carbon-coordinated transition metal nanocatalysts (CoC_<i>x</i>@C) for in situ, high-fidelity tracking of dopamine (DA), a key modulator of neurological function. The engineered coordination structure facilitates rapid, selective multielectron DA oxidation, while its modulated d-band center minimizes nonspecific interfacial adsorption, yielding 278-fold sensitivity and 333-fold selectivity improvements over conventional electrodes. Longitudinal DA tracking across multiple models with this platform reveals novel insights into GBM-associated neural dysfunction. This work provides the first electrochemical evidence of neurotransmitter-mediated tumor-neuron interplay and offers a robust tool for cancer neuroscience investigations and beyond.