Foundation model cascades enable zero-shot microscopy image analysis for cell therapy manufacturing
By combining pre-trained foundation models in a complementary cascade, our method provides a generalizable solution for real-time process monitoring and feedback control, paving the way for more scalable and automated cell therapy manufacturing.
Authors
- Krishnendu Roy (ORCID: https://orcid.org/0000-0002-9972-0950)
- Christine E. Brown (ORCID: https://orcid.org/0000-0003-4915-8207)
- Benjamin Joffe (ORCID: https://orcid.org/0000-0001-8574-0136)
- Rui Qi Chen (ORCID: https://orcid.org/0000-0002-4640-8592)
- Stephen Balakirsky (ORCID: https://orcid.org/0000-0003-0757-6152)
- Bharat Kanwar (ORCID: https://orcid.org/0000-0002-6362-7017)
- Paloma Casteleiro Costa (ORCID: https://orcid.org/0000-0002-7824-9805)
- Susan B. Liu
- Linda Kippner (ORCID: https://orcid.org/0000-0003-0263-0279)
- Aaron D. Silva Trenkle (ORCID: https://orcid.org/0000-0001-9331-6191)
- Francisco E. Robles (ORCID: https://orcid.org/0000-0003-4413-9779)
- Isaac LeCompte
- Jing Li
- Ye Li
- Yeonju Lee
- Caroline E. Serafini
- Bryan Wang
Institutions
- Georgia Institute of Technology (US)
- Vanderbilt University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- City of Hope (US)
Publication Details
- Journal
- Cytotherapy
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1016/j.jcyt.2026.102078
- Primary Topic
- Advanced Fluorescence Microscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00