Establishment of accurate estimation equations for area under the concentration curves using simultaneous limited sampling for extended-release tacrolimus and mycophenolic acid in kidney transplant recipients
Four equations (C0-C1-C6, C0-C1-C2-C6, C0-C1-C3-C6, C0-C1-C4-C6) showed strong correlations with the actual AUC (R² > 0.95), with the validation identifying C0-C1-C3-C6 as the most reliable for both TAC-ER and MPA. This study demonstrated that LSS using C0-C1-C3-C6 reliably and accurately estimated both the actual TAC-ER AUC0-24 and MPA AUC0-12 simultaneously in kidney transplant recipients. These equations can be feasibly implemented in outpatient clinical settings to reduce time and cost.
Authors
- Takehiro Ohyama (ORCID: https://orcid.org/0000-0002-2223-0769)
- Makiko Mieno (ORCID: https://orcid.org/0000-0002-3510-9941)
- KIYOHIKO HOTTA
- Toshimasa Nakao (ORCID: https://orcid.org/0000-0003-1003-6800)
- Hajime Sasaki (ORCID: https://orcid.org/0000-0001-7639-0912)
- Kyoko Minamisono (ORCID: https://orcid.org/0000-0001-6952-0328)
- Sho Nishida (ORCID: https://orcid.org/0000-0002-1810-2772)
- Takayuki Hirose
- Daiki Iwami
Institutions
- Jichi Medical University (JP)
- Sapporo City General Hospital (JP)
- Jichi Medical University Hospital (JP)
- Spanish Oncology Genitourinary Group (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-03
- DOI
- https://doi.org/10.3389/fimmu.2026.1710261
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hokkaido University