The role of preoperative antibiotic prophylaxis in the relationship between intestinal colonization and post-ERCP biliary tract infection: a prospective cohort study
Our analysis did not find significant evidence that intestinal colonization independently increases PEBTI risk. The observed associations appear to be largely confounded by patient vulnerability factors, with no significant evidence of mediation by antibiotic prophylaxis. These findings suggest prioritizing host-directed prevention strategies over pathogen-directed interventions in clinical practice.
Authors
- Zhenjuan Li (ORCID: https://orcid.org/0000-0003-0037-6596)
- Jiangfeng Zhang (ORCID: https://orcid.org/0000-0003-2616-6722)
- Junzhe Bao
- Leilei Guo
- Yuanyuan Li
- Yuzhu Wang
- Peng Li
- Junping Liu
- Mingjie Sun
- Shichao Zhu
- Bin Hu
- Yin Chen
Institutions
- Zhengzhou University (CN)
- Zhumadian Central Hospital (CN)
- Henan Provincial People's Hospital (CN)
- Zhengzhou Central Hospital (CN)
- Nanyang Medical College (CN)
- Zhengzhou People's Hospital (CN)
Publication Details
- Journal
- Antimicrobial Resistance and Infection Control
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s13756-026-01707-w
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00