Proteomic antibacterial characterization of flavonoid xanthohumol and probiotic Clostridium butyricum on pathogenic Clostridioides difficile
Our study demonstrates that xanthohumol and Clostridium butyricum attenuate the pathogenicity of Clostridioides difficile through modulation of lysine acetylation and disruption of glycolysis metabolism. These findings highlight their potential as promising therapeutic strategies for treating Clostridioides difficile infection.
Authors
- Guorong Li
- Shenkun Wei
- Xinping Zhu
- Wei Chen
- Xia Liu
- Zijian Chen
- Mengyi Liu
- Qiong Yang
- Junjie Liang (ORCID: https://orcid.org/0009-0002-0986-9872)
- Jun-Yu Xu
Institutions
- Nanjing University of Chinese Medicine (CN)
- Chinese Academy of Sciences (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Shanghai Institute of Materia Medica (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1186/s13020-026-01343-x
- Primary Topic
- Hops Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Shanghai Rising-Star Program
- Zhongshan Science and Technology Bureau
- National Key Research and Development Program of China