Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

Our results suggest that the therapeutic effects of XQHF may be attributed to the synergistic actions of its multiple active constituents, which collectively suppress the inflammatory cascade and attenuate pyroptosis, thereby alleviating lung injury. Furthermore, both <i>in vivo</i> and <i>in vitro</i> experiments demonstrated that XQHF modulates sepsis-induced acute lung injury, at least in part, through the inhibition of the NLRP3/Caspase-1-dependent pyroptosis signaling pathway.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-02-03
DOI
https://doi.org/10.3389/fimmu.2025.1709586
Primary Topic
Inflammasome and immune disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

Xiaodong Li, Jun Zhang, Qingquan Liu, Can Lei et al.
Frontiers in Immunology
Inflammasome and immune disorders
article

Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism

Xiaodong Li, Jun Zhang, Qingquan Liu, Can Lei, Kangli Wang, Xiaolong Xu, Tianfen Cen
article en

Abstract

Our results suggest that the therapeutic effects of XQHF may be attributed to the synergistic actions of its multiple active constituents, which collectively suppress the inflammatory cascade and attenuate pyroptosis, thereby alleviating lung injury. Furthermore, both <i>in vivo</i> and <i>in vitro</i> experiments demonstrated that XQHF modulates sepsis-induced acute lung injury, at least in part, through the inhibition of the NLRP3/Caspase-1-dependent pyroptosis signaling pathway.

Frontiers in ImmunologyVol. 16
Beijing University of Chinese Medicine (CN), Capital Medical University (CN), Hubei University of Chinese Medicine (CN), State Administration of Traditional Chinese Medicine of the People's Republic of China (CN), Wuhan City Chinese Medicine Hospital (CN), Hubei Provincial Hospital of Traditional Chinese Medicine (CN), Tongren Hospital (CN), Xian Yang Central Hospital (CN), Beijing Hospital of Traditional Chinese Medicine (CN), Anyang Hospital of Traditional Chinese Medicine (CN)
Natural Science Foundation of Hubei Province
Good health and well-being
Openalex Percentile: Top 68%
Inflammasome and immune disorders
DOIOpen Access PDFOpenAlex
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Xuanqing Hefa formula relieves sepsis-triggered acute lung injury by targeting the NLRP3/Caspase-1 pyroptosis mechanism — Xiaodong Li, Jun Zhang, et al. · Frontiers in Immunology (2026) | TGRS Research Map | TGRS