Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease
Comprehensive lipidomics analysis of frontal cortex from controls, Alzheimer's disease (AD) patients and resilient individuals. ω6 Oxylipins, markers of neuroinflammation, are increased in both AD and resilience. Resilient donors have reduced triacylglycerols and lipid droplets compared to AD. Multi-omics integration shows a molecular response to amyloid beta plaques associated with ω6-derived oxylipins and loss of interneurons.
Authors
- Daan van der Vliet (ORCID: https://orcid.org/0000-0001-7317-9679)
- Dennis Wever (ORCID: https://orcid.org/0000-0002-0801-4453)
- Joost Verhaagen (ORCID: https://orcid.org/0000-0002-8341-1096)
- Amy C. Harms (ORCID: https://orcid.org/0000-0002-2931-4295)
- Marielle van der Peet (ORCID: https://orcid.org/0000-0001-8155-1485)
- Mario van der Stelt (ORCID: https://orcid.org/0000-0002-1029-5717)
- Xinyu Di (ORCID: https://orcid.org/0000-0002-2785-9320)
- Brechtje de Jong
- Inge Huitinga
- Luuk E. de Vries
- Marc T. C. van der Meij
- Thomas Hankemeier
- Dick F. Swaab
Institutions
- Leiden University (NL)
- Netherlands Institute for Neuroscience (NL)
- Royal Netherlands Academy of Arts and Sciences (NL)
- Netherlands Metabolomics Centre (NL)
- Oncode Institute (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1002/alz.71083
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Hersenstichting
- Alzheimer Nederland