Development and validation of the INFLammation in Acute Myocardial diseases risk Estimation for Myocardial Infarction (INFLAME-MI) score
INFLAME-MI is a novel, rapid, and easy-to-use risk score for in-hospital mortality after AMI, derived from common inflammatory indices. In external validation, it demonstrates comparable discrimination, improved calibration, and higher net benefit at ≤7% thresholds compared with the GRACE score, particularly within key decision-making ranges. Further work is needed to establish the INFLAME-MI score through validation of these findings in diverse, prospective patient cohorts.
Authors
- Daniel I. Bromage (ORCID: https://orcid.org/0000-0002-4243-5964)
- Mohammad Al-Agil (ORCID: https://orcid.org/0000-0001-6292-9657)
- Fulye Argunhan (ORCID: https://orcid.org/0000-0001-7616-2151)
- P V Scott
- Matthew Sadler
- Lynn Swun Quek (ORCID: https://orcid.org/0000-0003-0221-5761)
- Sarah Mackie
- Cristina Madaudo (ORCID: https://orcid.org/0000-0002-9151-4335)
- Aamir Shamsi (ORCID: https://orcid.org/0000-0002-4142-7882)
- Narun Tantichirasakul
- Theresa McDonagh
- Antonio Cannata
- Rocco Andrico
- Lavan Muraleedharan
- Gautam Sen
- Gloria Lorenzon
- Susan Piper
- Ali Malik
- Enrico Fabis
Institutions
- British Heart Foundation (GB)
- Blood Cancer UK (GB)
- King's College Hospital NHS Foundation Trust (GB)
- King's College Hospital (GB)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2026-01-13
- DOI
- https://doi.org/10.1093/eurjpc/zwag035
- Citations
- 1
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 24.20