Happening in the Prostate Tumor Microenvironment: Ion Channels and Extrachromosomal DNA Driving Phenotypic Plasticity
Ion channels and ecDNA are central to the disease progression and treatment resistance of PCa through regulation of EMT, CSC phenotype, and tumor microenvironment (TME) interactions. Targeting the drivers-through ion channel modulators, ferroptosis induction, and ecDNA-targeting interventions (BET/HDAC inhibitors, CRISPR-based methods) offers a promising way to overcome resistance. Integration of multi-omics, and combination treatments will be key to construct precision medicine strategies and improve clinical outcomes in advanced PCa.
Authors
- Natasha Kyprianou (ORCID: https://orcid.org/0000-0002-8713-3599)
- Alfonso Urbanucci (ORCID: https://orcid.org/0000-0003-2931-3652)
- Goutam Chakraborty (ORCID: https://orcid.org/0000-0002-4387-2621)
- Sini Hakkola
- Ashutosh Tewari (ORCID: https://orcid.org/0000-0002-3146-4524)
- Sujit Nair (ORCID: https://orcid.org/0000-0002-7322-7375)
- Sara Darbandi
- Ahmed Eraky
- Juanita Gujral
Institutions
- Oslo University Hospital (NO)
- Tampere University of Applied Sciences (FI)
- Cancer Institute (WIA) (IN)
- Tampere University Hospital (FI)
- Tisch Hospital (US)
- Tampere University (FI)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- The Prostate
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1002/pros.70139
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00