Histotripsy-initiated immune response synergizes with chemotherapy in a neuroblastoma murine model
Mechanical ablation with histotripsy drives systemic antitumor immunity, reshapes the tumor microenvironment, and enhances chemotherapy efficacy in a syngeneic model of metastatic, high-risk neuroblastoma.
Authors
- Jacky Gomez-Villa
- Sonia L. Hernandez (ORCID: https://orcid.org/0000-0001-6188-0732)
- Lydia Wu (ORCID: https://orcid.org/0000-0001-8995-9223)
- Timothy L. Hall (ORCID: https://orcid.org/0000-0002-4867-2856)
- Mark A. Applebaum (ORCID: https://orcid.org/0000-0001-9766-8477)
- Kenneth B. Bader (ORCID: https://orcid.org/0000-0003-2384-3150)
- Fernando Flores-Guzmán
- Yuqing Xue (ORCID: https://orcid.org/0000-0002-8909-0270)
- Natalia L. Antonides-Jensen
- Samantha S Yee
- Muskan Singh
Institutions
- University of Michigan (US)
- University of Chicago (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-02-03
- DOI
- https://doi.org/10.64898/2026.01.30.702878
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Focused Ultrasound Foundation
- University of Chicago
- National Institutes of Health