Delayed anticoagulation is associated with lower mortality in sepsis-induced coagulopathy: a large-scale, propensity-score-matched cohort study from MIMIC-IV
Among critically ill patients with SIC, delayed initiation of anticoagulation was independently associated with improved short- and medium-term survival. These findings support a phenotype-guided, time-stratified approach to anticoagulation in sepsis and highlight the need for prospective trials to validate optimal timing strategies.
Authors
- Tiantian Zhou (ORCID: https://orcid.org/0000-0002-6508-8694)
- H. Liu
- Fengxia Qin (ORCID: https://orcid.org/0009-0000-7256-1884)
- Jin Liang Zhu
- Xiaofei Huang
- Haibin Ni (ORCID: https://orcid.org/0000-0003-1726-7943)
- Lei Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Jiangsu Provincial Academy of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1097/js9.0000000000004773
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00